Introduction: Colon is frequently affected by wide variety of lesions ranging from inflammatory to neoplastic processes. Colorectal cancer is the fourth ranking cancer worldwide, accounting for approximately 9% of all cancers. Adenocarcinomas are the commonest tumors in colorectal region. Aims and Objectives: 1. To study Spectrum of malignant colonic lesions in our institute and compare the  ndings with other studies. 2. To study age, gender, clinical presentation and site wise distribution of lesions. 3. To study prognostic factors in colorectal carcinomas with emphasis on Histopathological staging. Material methods: This is a 1-year and 8 months retrospective and prospective study from Jan 2018 to August 2019 done in pathology department, DVVPF’s medical college and hospital. Samples included are endoscopic biopsies and surgically resected colonic specimens received from department of General surgery. Sample size- 45. Age, gender and presenting complaints were also studied along with histomorphological analysis. Details of microscopic examination were noted for staging of lesions as per Modified Duke’s staging system. Results and discussion: Colorectal carcinoma is common with increasing age in 48.89% of cases, commonly presenting with bleeding per rectum (53.33%). Rectum was common site noted in 31.11% cases. Adenocarcinomas are common histological type of colorectal carcinoma. Conclusion: Grading and staging are important prognostic factors in colorectal carcinomas affecting the extent of surgery, follow-up treatment and to avoid the risk of tumor recurrence.

Keywords: Adenocarcinoma; Colorectal cancer; Grading; Staging.