Objective: Our study aims to study the overall obstetrical and neonatal outcomes in spontaneous conception versus IVF conception. Study design: Hospital based prospective study Methods and Materials: The study was conducted at our hospital over a period of one and a half years from September 2014 to April 2016. It was a hospital based prospective study. A total of 100 (50 spontaneous conception and 50 IVF conception) women who were admitted for safe confinement at Obstetrics and gynecology department of hospital were included in the study. For the purpose of the study, the study group was divided in two groups IVF conception group and spontaneous conception group for comparison of obstetrical and neonatal outcome. A detailed history was taken and thorough examination findings were noted. The antenatal course was noted and also the obstetric and neonatal outcomes were noted. Results: It was observed that the obstetrical outcomes were poorer in IVF conception group than in the spontaneous conception group. Significant association was found between gestational duration, mode of delivery, NICU stay requirement with mode of conception. Association was also found between antepartum hemorrhage (APH), preeclampsia, gestational diabetes, postpartum hemorrhage (PPH) with mode of conception. Conclusion: Maternal age, gestational duration, preterm delivery, LSCS deliveries, low-birth weight babies, low APGAR score, and requirement of NICU stay in IVF conception group was significantly higher than in spontaneous conception group. Association was also found between antepartum hemorrhage, preeclampsia, gestational diabetes mellitus, preterm premature rupture of membranes, postpartum hemorrhage with mode of conception.