Tuberculosis (TB) caused by the bacterial pathogen mycobacterium tuberculosis (MTB) is one of the oldest and hardiest diseases known to mankind. The primary site of infection is the lung, spread to other organs can be haematogenous or through lymphatics. 15–20% of all TB cases are extra-pulmonary TB (EPTB). In females, genital TB infection (FGTB) first strikes the fallopian tubes, followed by the endometrium and ovaries with devastating effects. Symptomatology is varied and vague with the commonest presentation being infertility and menstrual irregularity. Diagnosis is difficult due to the pauci-bacillary status and requirement for tissue biopsy. Increase in empirical treatment has contributed to the increase in drug resistance. The aim of these good clinical practice guidelines is to encourage a uniform, evidencebased practice for suspecting, diagnosing and managing female genital tuberculosis in an Indian setting.