Context: Uterine leiomyomas is the most common benign tumor of the uterus and one of the most frequent indications for operative procedures. High dose of mifepristone used to treat leiomyomas have resulted in side effects. Hence this study was done to evaluate effects of low dose mifepristone. Aims: To evaluate the effectiveness of low dose Mifepristone in the treatment of Uterine Leiomyoma. Settings and Design: A prospective observational study was conducted among 60 women diagnosed with uterine leiomyoma in a tertiary hospital at Karaikal. Methods and Material: Data was collected using standardized questionnaire. Blood investigation and ultrasound pelvis was done to evaluate the effects on uterine leiomyoma before and after treatment with 10 mg of mifepristone for three months. Statistical analysis used: Mean and standard deviations were used to present quantitative data. Association was tested using Chi square, McNemar test, Paired t test and Wilcoxin test. Results: Maximum participants were between 40-49 years. More than half of the study participants were relieved of dysmenorrhea after the treatment. The Mean PBAC values reduced from 124.6 ± 51.85 to 34.72 ± 17.87 which was highly significant. There was significant reduction in the uterine volume from 331.69 ± 216.05 to 239.68 ± 157.23 cm3 and the Leiomyoma volume from 68.62 ± 38.94 to 46.71 ± 27.96 cm3. About 78% of the study population experienced amenorrhea after the therapy. Conclusions: Low dose of Mifepristone was effective in reducing the size of uterine leiomyoma and also decreasing symptoms of dysmenorrhoea and menorrhagia thus improving the general health status and quality of life of the study population.