Background: Nephrotic syndrome causes a great morbility and mortality among the children. It is a characterized by massive loss of urinary protein along with risk of altered calcium metabolism. The aim of present study was to assess the serum calcium and vitamin D level in childhood Nephrotic Syndrome and try to find out correlation of biochemical parameters as severity in same subjects. Material and Methods: The present study was case-control study. Total 110 subjects were included and divided into two groups. Group I consisted 55 subjects of childhood Nephrotic Syndrome in the age group 1-10 years while Group II consisted of age and sex matched 55 normal healthy individuals who served as control with no history of childhood Nephrotic Syndrome. Serum levels of calcium, vitamin D were estimated in all the subjects under study. Other biochemical parameters like serum total protein, albumin, and creatinine were measured in all subjects. Values were expressed as mean ± standard deviation. SYSTAT version 12 software was used for statistical analysis. Comparisons of study groups to control groups were done by applying student t test. Results: Serum calcium and vitamin D level were decreased a childhood Nephrotic Syndrome compared with controls. Mean values of serum total protein, albumin, and creatinine were significantly (p<0.0001) lower in childhood Nephrotic Syndrome compared with controls. Conclusion: In the present study, It can be concluded that, childhood Nephrotic Syndrome is associated with abnormalities in the level of serum calcium and vitamin D. Serum total protein, albumin, and creatinine may be used as biochemical markers to determine severity of childhood Nephrotic Syndrome and it may beneficial for better management and for developing new treatment strategies.

Keywords: Childhood Nephrotic Syndrome; Calcium; Vitamin D.