The effect of thiamine hydrochloride against lead induced acute toxicity was experimentally studied in rats. Hematological parameters such as WBC count and differential count were determined and a decrease in their levels were observed throughout study period in the lead acetate induced animals. Cholesterol level was also found to be decreased throughout the period of study, in lead acetate induced animals. Biochemical alterations were reversed on treatment with thiamine hydrochloride due to its ameliorative role in lead induced rats.

Keywords: Lead acetate; Thiamine hydrochloride and WBC Count.