Background PerioGlas is an alloplastic bone graft material which is used for the treatment of intrabony defects. Among the alloplastic synthetic bone grafts, bioactive glass is an osteoconductive and steostimulative graft material which enhances bone formation in regenerative procedures. Method Efficacy of bioactive glass (PerioGlas) was assessed in 30 patients for the treatment of periodontal osseous defects and was compared to open flap debridement alone. Results Statistically significant improvements were demonstrated at 6 months post treatment in all the parameters studied. Mean probing depth reduction, clinical attachment level, radiographic bone fill were 4.27mm, 5.87mm, 3.27mm respectively for test sites and 4.43mm, 5.67mm, 2.25mm respectively for control sites at 6 months. Conclusions The results of the present study show that bioactive glass improves the healing outcomes regarding probing depth reduction, osseous defect fill, and gain in clinical attachment.