Introduction: Supraclavicular brachial plexus block provides anaesthesia of the entire upper extremity in the most consistent and time-efficient manner. The present study was undertaken to evaluate the time of onset, duration of sensory and motor block along with monitoring of heart rate, non-invasive blood pressure, and sedation. The analgesic efficacy of clonidine bupivacaine combination compared to plain bupivacaine for brachial plexus block by supraclavicular approach was also studied. Material and Methods: After institutional ethical committee clearance and prior informed consent, fifty patients aged 18 to 60 years undergoing upper limb surgery were included in the study after being divided into two equal groups: one with Bupivacaine – Clonidine (BC), another with bupivacaine (B) alone. Group BC received 30 ml of Bupivacaine 0.25% plus 1 μg/kg of clonidine with Normal saline to make a total of 1 ml and Group B received 30 ml of bupivacaine 0.25% plus 1 ml of Normal saline 0.9%. The onset as well as duration of sensory and motor block along with monitoring of heart rate, NIBP, sedation score were recorded. Results: The time of onset of sensory and motor blockades was fast in clonidine group along with prolonged duration of action of the same. There was no statistically significant difference between the two groups with regards to age, gender and weight (p>0.05). The mean duration of sensory block in group BC was 500.00 ± 104.61 min and in group B was 326.00 ± 58.31 min. The mean duration of motor block in group BC was 420.60 ± 94.23 min and the group B was 283.00 ± 54.85 min. The statistical analysis by unpaired student’s ‘t’- test showed that the duration of sensory and motor block in group BC was significantly longer when compared to group B (p < 0.001). Conclusion: This study concludes that clonidine is a better adjuvant to bupicaine for supraclavicular brachial plexus block; it provides faster, longer duration of analgesia and sedation with hemodynamic stability.