The present work was planned to determine if alternate nostril breathing (ANB) has any effect on central neural processing, by studying its effect on reaction time. In present study 20 male and 20 female, young medical students were practiced ANB for 3 months. Outcome assessments of auditory reaction time (ART) and visual reaction time (VRT) were performed at baseline and after the 3 month of ANB training. There was a statistically significant (P<.001) decrease in both ART and VRT. This decrease in ART and VRT after ANB practices may be due to increased mental alertness, a balancing effect of ANB on the functional activity of the left and right cerebral hemisphere or increased corticotrophin releasing hormone and cortisol secretion in response to a challenge. This is of applied value in situations requiring faster reactivity such as in day today driving, sports and in specialized surgery.