A retrospective study of 140 cases of poisoning received in the casualty of Rama Medical College Hospital and Research Center Hapur (Ghaziabad) Uttar Pradesh during a span of last 3 years (2014-2016) was done to know the socio-economic profile and pattern of acute poisoning in the region. All admitted and brought dead cases of acute, known and unknown poisoning, from all age were included in the study. Males and females were 62% and 38% respectively. Most common age group was 21-30 years and majority of victims were married. Most of the victims belonged to lower (33.6%) or lower-middle (60.7%) class. Organophosphate (37.1%) was the most common poisoning, followed by Celphos (21.4%) and other unknown poisoning (18.6%) responsible for more than two-third of the cases. Majority of poisoning cases (85.7%) were suggestive of suicide, of which family quarrel (31.7%) and unemployment (22.5%) or loss in business were more common in male and ill treatment by husband/in-laws (27.5%) in female.