Proteins are one of the most dynamic and versatile biomolecules which present in all the organisms. Protein plays a pivotal role in cell growth, cell motility, and biosignalling, provide immunity as well as cell recognition and many more biological processes like replication, transcription and repair.  Transcription factors are also protein which present in vicinity of various DNA sequences and by binding to these sequences they can upregulate or downregulate the expression of the particular gene. Some protein performs more than one function in body and some are specific for a particular function in the biological system. Cancer is one of the deadly diseases of present century. Cancer is abnormal growth of cells which can be generated by multiple unlimited cell divisions and form a lump or tumor which can be benign or malignant. At present era the role of protein in cancer is very much skeptical that weather it enhance metastasis or suppress the effect of cancer. Cancer is the second most deadly disease of century after the heart disease. This mini review is an effort to give a glimpse of indispensable role of protein in cancer.
Keywords: Protein; Cancer; F-Box Protein; Cell Proliferation; Apoptosis; Metastasis.