Background: Hypertension is the third leading killer disease in the world and is responsible for 1 in every 8 deaths. Uric acid has been associated with hypertension in many studies involving different population but results were controversial and no information was found on the association between vitamin D insufficiency and elevated uric acid. The aim of present study was to assess the serum uric acid and vitamin D level in essential hypertension and try to find out its correlation. Material and Methods: The present study was case-control study. Total 90 subjects were included and divided into two groups. Group I consisted 45 subjects of essential hypertension in the age group 25-75 years while Group II consisted of age and sex matched 45 normal healthy individuals who served as control with no history of essential hypertension. Serum levels of uric acid, vitamin D were estimated in all the subjects under study. Values were expressed as mean± standard deviation. SYSTAT version 12 software was used for statistical analysis.Comparisons of study groups to control groups were done by applying student t test. Pearson’s correlation coefficient was used to find out the correlation between two variables. Results: Serum uric acid level was increased significantly (p<0.001) in essential hypertension as compared with controls. Correlation between uric acid and diastolic blood pressure and systolic blood pressure was positively correlated and significant. Correlation between Vitamin D and diastolic and systolic blood pressure was negatively correlated and non- ignificant. Conclusion: In the present study,It can be concluded that, the essential hypertension is associated with abnormalities in the level of serum uric acid and vitamin D. Serum uric acid and vitamin D can be used as biochemical markers to determine severity of hypertension and it may be beneficial for better management and for developing new treatment strategies. 

Keywords: Essential Hypertension; Uric Acid; Vitamin D.