Background: Neurodevelopmentaltherapy (NDT) refers to those activities that enable the child to practice the perfect skills. These types of exercises are used to improve movement and postural reactions; thereby it improves gross motor function in children with cerebral palsy. The specific objective of the study is to evaluate the effect of NDT in gross motor function of children with cerebral palsy.Methods: This study is a one group pre test post test design. 10 children with cerebral palsy were selected and assigned in one group. Pretest value of gross motor function was measured on first day of the NDT program. NDT was given three sessions a week, for three months. At the end of the NDT program, posttest gross motor function was measured.Major Findings: A mean improvement in gross motor function after NDT was 10.84 with SD of 6.84 and the t value of 5.012 was observed in this study. The obtained t value was significant at the level of p<0.001.