Pregnancy is a period where the mother tends to take care of herself so as to prepare herself for safe delivery. Many pregnant women experience discomforts of pregnancy that are not serious but detract from the woman’s feeling of comfort and well-being. The purpose of this study was to identify the prevalence of minor ailments of pregnancy and to assess the knowledge regarding selected minor ailments among antenatal mothers. Methods: The present study used a descriptive survey design. Sixty antenatal mothers attending Obstetrics and Gynecology OPD, AIMS, Kochi were selected using quota sampling technique including 30 primigravida and 30 multigravida mothers. Demographic variables and knowledge regarding minor ailments of pregnancy were collected using a semi- structured questionnaire. The prevalence of minor ailments of pregnancy was identified by a checklist. Data analysis was done by using descriptive and inferential statistics like frequency, percentage and t- test. Results: The most common minor ailments were frequency of micturition(80%), nausea and vomiting (80%), fatigue(80%), back pain(70%) and leg cramps(55%). Knowledge regarding minor ailments of pregnancy was good in 54%, average in 41% and poor in 5%. There was no significant difference between knowledge and prevalence of minor ailments between primi and multi gravida. Conclusion: The result of the study suggest that health education should be provided to all the antenatal mothers regarding minor ailments of pregnancy and its management.