There are significant differences among the three regions of Andhra Pradesh in terms of physical, meteorological and socio-economic characteristics. To ensure inter-regionally equitable development, several committees and special Regional Development Boards are constituted to suggest and over see the execution of special schemes for the development of backward regions in the state. However, the regional disparities persist even after five decades of economic planning in Andhra Pradesh., An attempt is made in this paper to analyze the backwardness of Rayalaseema region during 1993-04 – 2001-02. It is also attempted to identify the factors retarding the economic progress of the region and to suggest feasible measures to promote the progress and growth of Rayalaseema region.