Background:  Periodontitis is a chronic inflammatory reaction to a specific group of bacteria that results in destruction of supporting connective tissue and bone of the dentition. An interrelationship between periodontal disease and systemic health has been suspected for centuries. Recent evidence suggests that periodontitis may significantly affect systemic health conditions such as cardiovascular disease, cerebrovascular disease, diabetes, respiratory diseases and adverse pregnancy outcomes. Objective:  To find out the relation between chronic periodontitis and COPD using serum CRP as a potential marker. Methods: Thirty patients aged between 30–60 years were selected. Patients were divided into two groups, Group A comprised of 15 patients diagnosed as COPD with chronic periodontitis and Group B comprised of 15 patients diagnosed as chronic periodontitis only. Results: In this study C-reactive protein levels are significantly increased in both the groups. In group A, (patients with COPD with chronic periodontitis) the CRP levels were 4 times more than in group B (patients with Chronic periodontitis). The parameters evaluating gingival status revealed that GI, PBI and PI scores were highly significant in group B. Conclusion:  Periodontitis may add to the inflammatory burden of the individual and could contribute at least in part to the increased risk for COPD associated with elevated CRP levels in these patients based on serum CRP levels.