This short communication article was intended to update the literature on quality of life (QoL) or Health-related quality of life (HRQoL) among people living with HIV/AIDS (PLWHA). QoL evaluation was recommended for a holistic assessment of impact of disease and treatments in PLWHA. Many generic and disease-specific self-report instruments are available, including Medical outcome study measures which were reported for their reliability and validity, and available in multiple languages for use. Some treatments like anti-retroviral therapy, exercise therapy, nutritional therapy were shown to improve QoL in PLWHA.