Musculoskeletal disorder is a major health problem in the working population. The probable cause might be the economic growth and technological improvements in the working sector, which lead to greater interaction between man and machines. It is practically impossible to find an office or a shop floor without a computer workstation. Rapid development of technology, visual display terminals or display screen equipment (DSE) is a common constituent of the modern workplace. Spending long hours before computers has become compulsion due to work urgency, accuracy and demand, without giving attention to the individuals’ health, especially body weight. In this backdrop, the present study has been undertaken to find out the relationship, if any, between works related musculoskeletal discomforts and obesity indices among the human resources engaged in human computer interface job. Cornell Musculoskeletal Discomfort Questionnaire (CMDQ) scores have been calculated among 39 computer operators of age range 25-35 years. Significant association was observed between different obesity indices with CMDQ scores (P < 0.01).