Goat is one of the main live stock animal it has much adaptive capabilities to disease resistance. Goat mainly used as protein source which combat the malnutrition as well as employment generation in the west Bengal. Some time few microorganism can infect the goat as well as protein is lost. The role of protein, as a lipostatic signal makes it one of the best physiological markers for body weight, food intake, energy expenditure and reproduction. Information regarding molecular characteristics of protein in different animal species is scarce. With the aim of characterizing the protein of Black Bengal goat of normal and healthy at molecular level, the present study was designed to isolate goat protein from its adiposites of both normal and diseased and molecular characterization of the same, subsequently. In the present study, chemical treatment and ultra-sonication technique was used for isolating protein from goat adipose tissue. The isolated protein are subjected to SDS-PAGE from both normal (healthy) and diseased goat (PPR Infected) respectively. There were protein profile variation in both normal (healthy) and diseased goat (PPR Infected).