Chronic myofascial pain of cervical spine and shoulder is often related to faulty posture. Extended period of screen usage, faulty posture and sedentary lifestyle exacerbate tightness and weakness of back and core muscles. Excessive strain on the surrounding muscles and cervical spine leads to inter vertebral strain and spinal misalignment, and spine shaped like a “question mark” exaggeration of lumbar spine lordosis and excessive kyphosis of the thoracic spine. A bad posture can cause the musculature of the neck and upper back to strain excessively, which can irritate the spinal accessory nerve (SAN) and dorsal scapular nerve (DSN). A 5-in-1 trigger point and hydro-dissection technique has been described by Tang et al that specifically target trapezius, rhomboids, levator scapulae, and hydro dissecting the DSN and SAN to provide pain relief. We report ten patients of chronic myofascial upper back and neck pain managed by 5-in 1 block. Conclusions: 5-in 1 block is a good treatment option for patients suffering from chronic upper back and, neck pain and multidisciplinary approaches are essential.