Introduction: Spinal anaesthesia is a widely used anaesthetic technique. But sometimes the failure of spinal anaesthesia occur because of reasons like obesity, poor positioning, spinal deformity like kyphosis, misplaced injection and local anaesthetic resistance. Resistance to local anaesthetic is one of the reason. The mechanism of action of local anaesthetics is through sodium channels and mutation in the sodium channel could be one of the possible reasons for the resistance. Case Report: A 52-year-old man who has been experiencing excruciating stomach ache for three days. After receiving a diagnosis of acute appendicitis, he was scheduled for an open appendectomy while under spinal anesthesia. His laboratory results and general physical examination during the pre-anesthesia evaluation were normal, with an ASA grade I. A 25G Quincke’s spinal needle was used to do a lumbar puncture at the L3-L4 area while the patient was seated and under aseptic precautions. The subarachnoid area was injected with 30 mcg of buprenorphine and 0.5% hyperbaric bupivacaine. The patient was then placed in a supine position. General anesthesia was administered for the procedure after two successive attempts at spinal anesthesia failed, as demonstrated by the pinprick method or by motor block, as demonstrated by lower limb movements. The surgery and immediate post-operative period was uneventful. The patient described a scorpion bite that occurred a year ago when asked about his medical history. Conclusion: Scorpion stings can lead to resistance to local anesthetics due to the venom’s effect on sodium channels, potentially causing failure or delay in spinal anesthesia. Awareness of a patient’s history of scorpion envenomation is crucial for effective anesthetic management.