Human Metapneumovirus (HMPV) is a significant respiratory pathogen responsible for a range of illnesses, from mild cold-like symptoms to severe lower respiratory tract infections, particularly in vulnerable populations such as young children, the elderly, and immunocompromised individuals. This review explores the clinical presentation, epidemiology, and transmission of HMPV, highlighting its seasonal nature and the challenges in controlling its spread. It also emphasizes the crucial role of nurses in both hospital and community settings. In hospitals, nurses are vital in early detection, infection control, supportive care, and patient education. In the community, they contribute to health promotion, early identification of symptoms, and prevention strategies. By providing comprehensive care, managing complications, and educating at-risk populations, nurses play an essential role in reducing the impact of HMPV and improving patient outcomes. This article underscores the importance of nursing interventions in managing HMPV infections and preventing their transmission.