Context: Emergency drugs are chemical drugs used in life-threatening conditions to control symptoms and save lives. As a front line workers, nurses have prime responsibility to develop adequate knowledge about emergency drugs. Aim: The aim of the study is to assess the level of knowledge regarding emergency drugs among staff nurses before and after teaching. Setting and Design: Guru Nanak dev hospital Amritsar, Punjab and Quasi experimental Research design with non-randomized Control group design. Methods and Material: The sample of 60 staff nurses in that 30 experimental group and 30 control group were selected by purposive sampling technique. The tools were demographic variables and structured knowledge Questionnaire regarding emergency drugs.Statistical analysis used: The collected data were tabulated, analyzed and interpreted by using descriptive and inferential method.Results: The results showed that in control group during pretest majority 19(63.3%) had poor knowledge and 11(36.7%) had average knowledge where as in experimental group maximum 18(60%) had poor knowledge and 12(40%) had average knowledge. In experimental group during posttest majority 23(76.7%) had good knowledge and 7(23.3%) had average knowledge where as in control group majority 17(5.7%) had poor knowledge, 13(73.3%) had average knowledge and no one have good knowledge. Conclusion: Findings showed that structured teaching program was effective in improving the knowledge regarding emergency drugs among staff nurses in Experimental group as compared to control group.