Objective: Osteoarthritis (OA) is a multifactorial degenerative disease characterized by a range of morphological and biochemical alterations to the joint capsule and synovial membrane, as well as bone hypertrophy and articular cartilage loss at the margins. Osteoarthritis (OA) is one of the most common causes of impairment in adults. This review aims to determine whether knee osteoarthritis and the state of cardiorespiratory health are correlated. Reviewing the relationship between knee osteoarthritis (OA) and cardiorespiratory health status is important because OA’s systemic effects are becoming more well-acknowledged. To improve quality of life and lessen the strain on healthcare systems, comprehensive management strategies that address not only joint health but also an individual’s total cardiovascular and respiratory well-being must take this relationship into account. Study design: Research articles were retrieved for this systematic review from reliable academic search engines such as Google Scholar, IEEE Xplore, Springer, and Elsevier. To obtain answers to the research questions, appropriate keywords are utilized in the literature search from reputable sources, such as Web of Science (WOS), and Scopus. The current study includes 80 papers. They underwent an extensive evaluation using the Prisma methodology for systematic review. Result and conclusion: Given that there is a favourable link between knee osteoarthritis (OA) and cardiorespiratory health status, this review has the potential to revolutionize the management of OA by promoting a more exhaustive treatment approach. Cardiorespiratory fitness assessments may be incorporated by medical professionals into standard OA treatment, resulting in specific therapies that promote cardiovascular and joint health. This may lead to increased cardiovascular health, increased mobility, and better overall patient outcomes, which would eventually save healthcare expenses and raise the standard of living for those who have osteoarthritis.