Leprosy, or Hansen’s disease, is a chronic infectious condition caused by Mycobacterium leprae, characterized by skin and peripheral nerve involvement. Theanaesthetic nature of leprosy lesions predisposes patients to unnoticed injuries, complicating the management of burns and chronic wounds. Burn injuries in leprosy patients are challenging due to delayed presentation, impaired healing, and increased susceptibility to infections. Advanced wound care modalities, including Autologous Platelet-Rich Plasma (APRP) and Low-Level Laser Therapy (LLLT), have emerged as promising solutions to address these challenges.APRP, rich in growth factors like PDGF, VEGF, and TGF-β, enhances angiogenesis, reduces inflammation, accelerates epithelialization, and promotes tissue regeneration, thereby improving wound healing. LLLT utilizes specific wavelengths of light to stimulate cellular activity, enhance microcirculation, boost collagen synthesis, and facilitate faster wound closure. When incorporated into a comprehensive management strategy, these techniques can significantly improve outcomes for burn wounds in leprosy patients. This article highlights the unique challenges of burn management in leprosy and emphasizes the role of advanced therapies such as APRP and LLLT in optimizing wound healing and reducing complications. A multidisciplinary approach combining these modalities with conventional wound care, infection control, rehabilitation, and patient education is essential for achieving favorable outcomes.