Since the onset of the COVID-19 pandemic, the widespread use of alcohol-based hand sanitizers for hygiene management has significantly increased their presence in households. This case report details a rare instance of acute isopropyl alcohol poisoning (AIpAP) in a 78-year-old female, who accidentally ingested hand sanitizer, mistaking it for a beverage. The patient presented with severe symptoms, including unresponsiveness and vomiting, requiring immediate medical attention. Despite the gravity of her condition, conservative treatment led to a full recovery. This case emphasizes the urgent need for public education on the safe storage and labeling of hand sanitizers to prevent accidental ingestion and highlights the importance of considering AIpAP in the differential diagnosis of unexplained consciousness disorders