Oral squamous cell carcinoma, commonly referred to as oral cancer, is considered to develop as a result of multi-hit process that involves a number of aberrant genetic events. Determining which event leads to the eventual development of oral cancer can be of a great significance in its prevention and control. p53 a tumor suppressor gene, in its mutated form is believed to exert tumorigenic influences and has been a subject of intensive study over several years in order to understand its role in the process of carcinogenesis.