ntroduction: Oral antivirals for Hepatitis B treatment are relatively safe but rarely  complications are described. We hereby describe a case of chronic kidney disease (CKD)  with Hepatitis B infection who presented with muscle weakness due to rhabdomyolysis after  starting on Entecavir which recovered on stopping it. Case report: A 52 year old male, a patient of Diabetic Nephropathy, was initiated on dialysis  elsewhere and within few weeks developed jaundice and was screened positive for Hepatitis  B with high viral load. Entecavir was initiated, 5 days later he presented to us with leg pains  and quadriparesis. On evaluation, he had deranged liver function test (LFT),elevated LDH and  CPK levels. We stopped Entecavir as we noted reports of rhabdomyolysis with Entecavir with statin  combination. He was hydrated appropriately. Haemodialysis was continued. The patient showed gradual improvement in LFT and quadriparesis. The learning point  from this case was identifying the complication and taking action for good outcome. Conclusion: This is the first case of drug (Entecavir) induced Rhabdomyolysis in a patient  with CKD, Acute Hepatitis B, presenting with quadriparesis. Entecavir may be avoided in  CKD patients in whom Tenofovir Alafenamide may be safer.