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Indian Journal of Obstetrics and Gynecology

Volume  12, Issue 2, April - June 2024, Pages 63-69
 

Original Article

Can Probiotics Play a Major Role as an Adjunctive Therapy in Treatment of Bacterial Vaginosis?

Bandana Sharma1 , Pavika Lal2 , Rashmi Yadav3 , Divya Dwivedi4 , Himani Malviya5

 1 Professor, 2-4Associate  Professor, 5 Senior Resident, Department of Obstetrics  and Gynaecology, Ganesh Shankar Vidyarthi  Memorial Medical College, Kanpur 208002, India.

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DOI: http://dx.doi.org/10.21088/ijog.2321.1636.12224.3

Abstract

Background: Bacterial Vaginosis is one of the most common causes of abnormal vaginal  discharge in women of reproductive age, which can have a major impact on quality of life.  Although the treatment course of oral metronidazole for 7 days results in curative rate  of 70%–80% at four weeks of treatment, but is associated with high rates of recurrence  occurred within twelve months, reaching up to 40%–50%. Methods: A Randomized Prospective Interventional Study was done on 1000 reproductive  age group females (pregnant or non-pregnant) diagnosed with bacterial vaginosis from  November 2020 to October 2022 at department of Obstetrics & Gynaecology, Kanpur. The  study group were divided into two subgroups - Group 1 were given metronidazole 500  mg for 7 days and probiotics for 14 days and group 2 were given metronidazole 500 mg  for 7 days and placebo for 14 days. The patients were followed after 3 months to know the  recurrence. Results: Majority of patients belonged to rural background (63.1%) with lower  socioeconomic (46.6%) and belong to age group 20-35 years. It was observed that there  was significant change in Amsel’s criteria and Nugent’s scoring in Group 1 as compared to  Group 2. The rate of recurrence at the end of the treatment for Amsel’s criteria in group 1  were 1.03 as compared to group 2 was 1.68 and for Nugent’s scoring, the rate of recurrence  at the end of treatment in group 1 was 3.17 as compared to group 2 was 4.78. Conclusion: Probiotics can be considered as one the adjuvant therapy for treating bacterial  vaginosis and re-establishing equilibrium in the vaginal microflora thus, preventing the  recurrences.


Keywords : Bacterial Vaginosis; Reproductive age group females; Probiotics; Recurrence.
Corresponding Author : Himani Malviya