Pathology is the discipline of diagnosing a disease mostly through analysis of tissues cell   and body fluid samples. Over the past few years, deep learning has created quite a hype about  artificial intelligence in healthcare. The practice of diagnostic pathology has gone through a  transformation wherein new tools such as digital imaging, advanced artificial intelligence  algorithms and computer aided diagnostic techniques are being used for assisting, augmenting and empowering the computational histopathology and AI enabled diagnostics. This is paving the way for advancement in precision medicine in cancer. In this article, the milestones and  landmark trials in computational pathology are discussed along with emphasis on future  directions.5