Presently, network pharmacology is being  popular in investigating the probable interaction of  secondary metabolites from herbal medicines with  multiple proteins involved in the various disease  pathogenesis and understanding the probable  molecular mechanism. The concept is based on  the multi compound-multi protein interaction and  somewhat different from a lock and key concept  of drug discovery. In this context, this minireview highlights the major aspects of network  pharmacology during the conceptualization of  herb-disease interaction.