AbstractAcute, rapid, and severe bone loss (ARSBL) and a high fracture rate exceed postmenopausal and age related osteoporosis in many bone illnesses. Drug induced systemic disorders, weakness, immobility, and the sickness dominate these situations. Examples include GIOP, post-transplantation bone disease, stroke, and acute spinal cord injury immobility. These disorders cause 8% spinal bone loss and 5% hip bone loss annually. Effective management can reverse bone loss. This review covers quick and severe bone loss causes.