Lung and breathing problems are common and 5th leading cause of death in worldwide. In India, the respiratory disorder stands in the 3rd place including COPD, asthma, pneumonia, tuberculosis etc. When a patient is unable to maintain a patent airway, adequate gas exchange or both, more invasive support with intubation and mechanical ventilation is needed to save the life of patient. Mechanical ventilation is a method to mechanically assist or replace spontaneous breathing, the most used mode of life support in medicine today, but it is not without complications. Physiologic complications associated with mechanical ventilation include ventilator induced lung injury, cardiovascular compromise, pneumothorax and the most importantly ventilator associated pneumonia.