Background: Coronary heart disease is one of the leading cause of mortality in the world. D-dimer is direct marker of on going coagulation with fibrinolysis and high sensitive-C reactive protein not only marker of low grade chronic systemic inflammation but also directly involved in atherosclerosis.

Objectives: The aim of present was to investigate the diagnostic potential of the plasma D-Dimer and high sensitive-C reactive protein as inflammatory markers in Coronary heart disease.

Methods: In present case-control study 265 with various types coronary heart disease (age range 26 to 75) and 120 healthy age and sex matched volunteers formed the control group. Nyco Card reader was used for plasma D-Dimer estimation whereas high sensitive C-reactive protein was estimated by Latex turbidimetric method. Statistical software SYSTAT version-12 was used to analyze the data. Values were expressed as mean ± standard deviation and Comparisons of study groups and study groups to control groups were done by applying Z test. one way analysis of variance (ANOVA) test and tukey-Kramer multiple comparison test were used comparison.

Results: Plasma D-Dimer and high sensitive C-reactive protein levels were significantly higher (p<0.01) in patients with Coronary heart disease like Stable Angina, Unstable Angina and Myocardial Infacrction as compared to healthy controls.

Conclusion: D-Dimer seems to be independent cardiovascular risk factors, which might add relevant information. Circulating level of hs-CRP was significantly increased in patients with all types of Coronary heart disease but patients with Stable Angina had low level of high sensitive-C reactive protein as compared with patients with Unstable Angina and Myocardial infarction which shows that its role as acute inflammatory marker.