Skin grafting is a technique that has been used to cover wounds since time immemorial. Various factors affect the take of the graft. If graft take is inadequate, it adds to the morbidity of the patient in terms of additional hospital stay, repeat surgery, and chances of loss of the second graft as well. Various methods have been described in aiding the take of the graft. In this article we would like to highlight the use of topical nitroglycerin in improving the take of Full thickness skin graft.