Flaps have been used for a long time for closure of soft tissue defects by plastic surgeons and form an important part of the surgeon’s armoury, however 2% −22% of flap procedures led to necrosis in an observational study.1 The search for an ideal intervention for ensuring flap survival still continues. Topical nitroglycerine has been found effective in prevention of flap necrosis in few studies.2-4 In this article we share our experience with prevention of flap necrosis using topical nitroglycerine.