Objectives: Oral Squamous Cell Carcinoma (OSCC) is the most common cancer across the globe. The treatment of OSCC by surgery, chemotherapy, radiotherapy or any combination of these has an adverse effect on the Quality of Life (QOL) of the patients. The main aim of this study was to evaluate the Oral health related Quality of Life (OHRQOL) in OSCC patients after their treatment.

Study Design: A cross sectional questionnaire study.

Results: Data related to their Sociodemographic factors like age, gender, type of habit abuse, TNM stage of the cancer, and socioeconomic status were collected. After statistical analysis, it was found that patients who had the poorest quality of life were married males in age group of 41-50 years with a habit of tobacco+alcohol abuse. Also they belonged to Stage 4b and were undergoing treatment in form of chemotherapy+radiotherapy and they belonged to upper middle SES class of modified Kuppuswamy scale 2018.

Conclusion: This study considers the significance of interplay of a constellation of factors that have an impact on quality of life in patients undergoing OSCC treatment. Physicians must consider the interplay of all these factors for making decision in treatment plan for the patient.

Keywords: Oral squamous cell carcinoma; Oral cancer; Mouth neoplasm; Quality of life; Central Indian population.