The pathophysiological conditions of organisms can be revealed by the study of haematological profile. Three breeds of dairy cows of 02-07 years age groups namely, non-descriptive(ND), Red Sindhi (RS) and crossbred Jersey (CBJ) cows, were used in this study. From each breed nine cows were taken. The aim of the present study was to investigate comparative analyses of haematological profile of different breeds of dairy cows of Odisha which is useful to provide a baseline data for comparison with other breeds of cows. For Hb and PCV highly significant difference (p<0.01) was there among the three breeds of cows. For TRBC, MCV and MCH no significant difference was there among three breeds. For MCHC highly significant difference (p<0.01) is there between ND and CBJ cows and between RS and CBJ cows. For WBC significant difference (p<0.05) was there between ND and RS cows. For lymphocyte, neutrophil and basophil no significant difference is there among the different breeds of cows. For monocyte highly significant difference (p<0.01) is there among the three breeds of cows. For eosinophil highly significant difference (p<0.01) was there between ND and CBJ cows and between RS and CBJ cows. Keywords: ND, RS, CBJ, cows.