Background: Most ovarian cancers are detected in the late stages as there are nearly no clinical symptoms or signs  at the early stage. Its high mortality rate has made it one of the most investigated fields in gynecological oncology. Aim: To study correlation between serum tumor markers and histopathology in diagnosed and operated cases  of ovarian mass. Objectives: To study tumor marker levels in diagnosed and operated cases of ovarian mass and post operatively  with the histopathology of said specimen. Settings and design: This is a prospective observational study carried out in a tertiary health care centre over 2  years from October 2019 to October 2021. Materials and Methods: The study population included 50 women diagnosed with an ovarian mass and operated  for the same.  After obtaining consent from the patient, detailed history was obtained, physical examination was done to examine  the mass. Serum analysis for levels of tumor markers such as CA-125, b-HCG and Serum Lactate Dehydrogenase  were assessed. Patient was investigated using ultrasound and if required MRI studies was also done. Post operatively, specimens were sent for histopathological studies. Conclusion: Among the tumor markers researched in this study, serum LDH can detect and predict the  histological pattern of ovarian cancers as well as the malignant potential of the tumors. However, CA125 is able to  predict only the malignant potential of the tumor. Beta hCG has no role in predicting the histology or malignant  potential of tumors