AbstractPlatelet rich fibrin matrix, which is rich in growth factors, has been demonstrated to be beneficial in the treatment of non healing ulcers in recent research. Aim of this study is to evaluate the role of Platelet Rich Fibrin Matrix (PRFM) in wound management. In our study, after two session of Platelet Rich Fibrin Matrix (PRFM) application, the two third of the defect was cover with granulation tissues