Children developing malocclusion in the mixed dentition period are frequently delayed for treatment until all permanent teeth erupt. A stage of transition from primary to permanent dentition is the time period which mainly presents with malocclusion due to various factors. Among the problems most frequently seen in the mixed dentition period is anterior cross-bite. Interceptive orthodontics is usually carried out to reduce the severity of developing malocclusion. This case report includes case series of patients with different forms of malocclusion such as cross bite correction and correction of rotated single tooth treated with 2x4 appliance respectively. Anterior cross bite in early mixed dentition can have long term effects on growth and development. This appliance is used in early mixed dentition for both anterior cross bite and alignment of incisors. Treatment of younger children in the early mixed dentition period offers advantages in terms of stability and avoidance of future complications.