Viruses are the sub-microscopic infectious agents and are the smallest and simplest of all life forms. The family Flaviviridae contains several important viruses that cause diseases in domestic and wild animals. Some of these viruses are emerging as very important not only for animal health but also for public health as they are highly zoonotic. The viruses of veterinary importance in this family belong either to the tick-borne virus group or the mosquito-borne virus group. So this article describes about the diseases caused by the family flaviviridae, its epidemiology, susceptible host, pathogenesis, clinical findings, diagnosis, prevention and treatment and its public health significance