Abstract The Study to Assess the knowledge and attitude of OPD patients regarding COVID-19 in selected hospitals of Greater Noida, Uttar Pradesh was undertaken by 4th year B.Sc Nursing Students during the year 2020-2021 in partial fulfillment of the requirement for the degree of Bachelor of Science in Nursing at Galgotias University. Objectives: (1) To assess the knowledge regarding COVID-19 among OPD patients in selected hospitals (GIMS) of Greater Noida, Uttar Pradesh. (2) To assess the attitude regarding COVID-19 among OPD patients in selected hospital (GIMS) of Greater Noida, Uttar Pradesh. (3) To determine the correlation between knowledge and attitude of OPD patients regarding COVID-19. (4) To determine the association of knowledge and attitude OPD patients regarding COVID-19 with selected demographic variables. Methodology: Cross sectional study design was taken for this study. Setting: The study was conducted at Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. Sample size: The sample size was 50 OPD patients. Sampling Technique: The non probability purposive sampling technique was used. Methods of data collection procedure: Data were collected from the OPD patients to assess the level of knowledge and attitude by using structured knowledge questionnaire. The collected data were tabulated and analyzed by descriptive and inferential statistics. Results: The study reveals that the mean knowledge of OPD patients were 5.86. hence, it is to be interpreted that OPD patients were having moderate knowledge regarding COVID-19. The mean attitude of OPD patients were 4.51. hence, it is to be interpreted that most of OPD patients were having unfavorable attitude regarding COVID-19. Conclusion: The Current research was able to provide a broad evaluation of the COVID-19 Knowledge and attitude among clients in selected hospitals of Greater Noida, Uttar Pradesh. The results indicated that as the clients usually have a sufficient level of knowledge and unfavorable attitude regarding COVID-19. Keywords: Study to Assess; Patients regarding COVID-19; Partial Fulfillment of the requirement; Cross sectional study; The study reveals ; Attitude among clients.