Turmeric (Curcuma longa Linn) is extensively used as a spice and grownup wide throughout Indian landmass. Turmeric plant has been utilized in ancient drugs as a remedy for varied diseases together with cough, polygenic disorder and internal organ disorders. For the previous couple of decades, in depth works are done to ascertain the medicine actions of Turmeric and its extracts. Curcumin is that the main substance of Turmeric and evidenced for its anti-inflammatory drug, inhibitor, antimutagenic, antidiabetic drug, bactericide, hepatoprotective, medication and anticancerous medicine activities. This review provides update in the main on the medicine activities of the Turmeric, its extracts and plausible medicative applications of Turmeric beside their safety analysis.