Introduction: Nurse have important role in prevention of disease, as an ounce of prevention is worth a pound of cure. Knowledge about adaptation of several healthy lifestyle measures can help in prevention of coronary heart disease thus, serve as remarkable factor for reduction of mortality and morbidity related to coronary artery disease. Methodology: The conceptual is based on general system model by Ludwing von bertanlaffy. The study was conducted on a sample of 30 middle adult age people from selected areas of Gujarat. Purposive sampling technique was used for selecting samples. In the present study one group pre-test post-test research design was used. The tool used for study was structured knowledge questionnaire. The data were collected, tabulated and analyzed by using descriptive and inferential statistics. The level of significance was at 0.05 levels. Results: The study revealed that the mean Pre-test score was 10.73 and the mean post test score was 17.23, the results also shows that the Standard deviation of Pre-test score of Knowledge was 2.174 and Standard deviation of post test score of knowledge was 1.822. Conclusion: the study in tends to assess the effectiveness of information booklet regarding lifestyle modification on prevention of coronary artery disease in selected areas of Gujarat. The study reveals that the post-test knowledge score is higher than the pre-test knowledge score regarding prevention of coronary artery disease through lifestyle modification.