Over-The-Counter (OTC) analgesics are very commonly used in our country and sometimes taken without the doctor’s prescription. Though generally these medicines are considered safe, but they can produce complications when taken in excess doses. The authors report a case of an adolescent girl who consumed acetaminophen-ibuprofen combination pills present in her home for headache, which proved fatal. The authors aim to highlight and increase awareness about the hidden dangers in careless and unsupervised use of these medicines. The possibility of death with overdose of even commonly prescribed drugs should be understood, studied well and should be taught to patients to keep such medications away from their children. Accessibility and availability of OTC drugs should be restricted in accordance with the recommended daily usage.