Introduction: Renal cortical necrosis (RCN) is characterized by patchy or diffuse ischemic destruction resulting in diminished renal arterial perfusion due to vascular spasm and microvascular injury. In addition, direct endothelial injury particularly in setting of sepsis, eclampsia, haemolytic uremic syndrome (HUS) and snake bite may lead to endovascular thrombosis with subsequent renal ischemia. Aims: To study clinical features and laboratory parameters with outcome of acute cortical necrosis. Materials and methods: It is a prospective study carried out for a period of 2 years in 50 patients presenting with acute renal failure due to acute cortical necrosis.Age group ranged from 2 years to 65 years. Results: During this period the total 650 patients presented with acute renal failure . Out of which the biopsy proven renal cortical necrosis were 50 in number. Out of total 50 cases of biopsy proven acute cortical necrosis leading to ARF constitutes pregnancy related were 35 (70%), septicaemia cases were 6 (12%), post gastroentiritiscases were 3 (6%), HUS cases were 3 (6%), snake bite cases were 2 (4%), due to extensive burns was 1 (2%). Conclusion: Acute cortical necrosis is most common in female as the commonest cause is of obstetrical in nature. Management consisted of fluid balance and Dialyzes is life saving procedure during recovery period.

Keywords: Renal cortical necrosis; Dialyzes; Acute renal failure.