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Indian Journal of Genetics and Molecular Research

Volume  9, Issue 1, January–June 2020, Pages 23-27
 

Review Article

Mutation, the Structural Genetic Change: A Short Review

D K Sharma

Additional Professor and Head, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Raipur, Chhattisgarh-492099, India.

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DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.9120.3

Abstract

Mutation is an alteration that occurs in our DNA sequence, generally due to the error developed when the DNA is copied or as the result of environmental causes such as radiations like ultraviolet rays, cigarette smoke etc. On the whole, there are 3 kinds of DNA mutations, the base substitutions, the deletions and the additions. Mutation is the resource
of newness and it creates new forms of species, potentially instantaneously in a sudden jump. This was envisaged as a pouring evolution and limited by the contribution of mutations. Mutationism is one of the alternatives to evolution by natural selection. It is continued living both before and after the publication of Charles Darwin's 1859 book, ‘On the Origin of Species’. The whole human community is one species with the same genes. Mutation builds somewhat dissimilar translations of the similar genes, called alleles. Then meiosis and sexual reproduction combine different alleles in new ways to increase genetic variation. These little variations in the DNA series make each creature distinctive in its hair and skin color, dimension, form, figure, behavior and receptiveness of disease. These genetic dissimilarities are valuable in helping populations modify over time. Variations that help the living being go on to survive and to reproduce pass on to the subsequent
generations. The variations which obstruct the survival and the reproduction are abolished from that population. This progression of normal selection can lead to major changes in the form, appearance,
activities, behavior or functioning of the individuals in that population, in just a few subsequent generations.

 


Keywords : Replication; Polymerization; Mutagen; Phenotype; Translocation.
Corresponding Author : D K Sharma