Background: Neoplastic and non-neoplastic Gastrointestinal
tract (G.I) disorders are frequently encountered in clinical practice.
Upper gastrointestinal endoscopy is a common tool for diagnosis.
The common indication of upper gastrointestinal endoscopic biopsy
includes odynophagia, gastroesophageal reflux and dysphagia.
Endoscopic studies include biopsy for histopathological evaluation
in clinically suspicious lesions. Aims and Objectives: To study the
histopathological features in endoscopic biopsy of the gastric
lesions. To study the correlation between various histopathological
gastric lesions with age, sex and clinical presentation. To study
the association of H. pylori in various gastric lesions. Material and
Methods: The present study was done in the department of pathology
and Gastroenterology in Sri Manakula Vinayagar Medical College
and Hospital Pondicherry for 18 months. Detailed clinical history
was taken and endoscopic biopsies were obtained from the gastric
lesions. All the clinical and endoscopic findings of these cases
along with diagnosis were noted down. A total of 74 cases were
collected in the study period. Results: Average age of the patients in
the present study was 46.7 years with 65% males and 35% females.
The most common symptom reported by the patients in the present
study was upper abdominal pain (87.8%). Non-specific gastritis was
the most common diagnosis (48.7%) in the present study. H. pylori
was the second most common diagnosis (36.5%). Adenocarcinoma,
chronic gastritis and hyperplastic polyp/mucosa were diagnosed
in 8.1%, 4.1% and 2.7% of the patients respectively. Conclusion: Our
study confirms that non-specific gastritis and H. pylori gastritis are
the most common etiologies of dyspepsia.
Keywords: Histopathology; Gastrointestinal; Endoscopic biopsy;
H. pylori; Gastritis; Adenocarcinoma.