The objective of this study was to analyse some common antidepressants in pharmaceutical preparations. The antidepressants taken for analysis were Selective Serotonin Reuptake Inhibitors [SSRIs]. SSRIs were associated with the significantly lower risk of toxicity, but large number of deaths from SSRIs has occurred in combination with other drugs specifically tricyclic and tetracyclic antidepressants. There has been a lot of work in the characterisation of antidepressants in pharmaceutical preparations but still a rapid and reliable positive qualitative identification of SSRIs needs to be developed. In the present investigation, Fourier Transform Infra Red [FTIR] spectrophotometer in transmission and Attenuated Total Reflectance [ATR] mode was used to qualitatively identify pharmaceutical preparation consisting of Proxetine, Sertraline, Escitalopram, Fluvoxamine. The results suggested that both the modes provided greater sensitivity but the ATR mode has great potential for the characterisation of SSRIs.